네비게이션으로 바로가기본문으로 바로가기

POSTECH LabCumentary Kim, Tae-Kyung (Life Sciences)

Neuro-Epigenetics (NEPI) Lab

더 알아보실래요?

이전

10/53

다음

Neuro-Epigenetics (NEPI) Lab

Kim, Tae-Kyung (Life Sciences)

An intense memory from childhood is apt to stay with us throughout our entire lives, and content we go over time and time again preparing for exams often remains with us long after our grades are tallied. This kind of ability to remember specific things is possible as nerve cells in our brain react to specific stimuli and the storage of associated memories is prolonged. It is increasingly evident such characteristics of the human brain are shaped at the molecular level, as is the DNA of nerve cells and wide-ranging factors that affect its expression.

 

The Neuro-Epigenetics (NEPI) Laboratory led by professor Kim, Tae-Kyung at the Department of Life Sciences, POSTECH, takes note of the functions of the human brain, perceived as the most untapped and most complex area in the study of the human body. To develop better understanding of the cognitive behaviors that people demonstrate through within brain at the molecular level, the NEPI Lab is leveraging epigenetics, one of the latest emerging genetic research areas, to probe into how the human brain functions.

 

Epigenetics allows researchers to identify how respective genes within nerve cells react to external stimulus and ultimately manifest themselves. A poignant memory from our childhood may serve as a stimulus to trigger certain gene expressions and control brain functions, resulting in specific nerve cells being able to recognize such stimulus more accurately and function accordingly. Analyzing this mechanism could enable scientists to understand the interplay between stimuli and human cognitive behaviors. Inversely, it could be possible to artificially manipulate human cognitive activities in the absence of any stimulus.

 

The most notable research outcome ever produced by the Lab was also to become the world’s first to identify enhancer RNAs or eRNA which regulate gene expression within DNA. While eRNA is known for its close correlation with gene expression, research on its function still has a long way to go. In addition to basic biochemical experimentation, the Lab is undertaking whole genome research to spot active sites by analyzing the whole genome within the brain. In tandem with this, researchers are also proceeding with behavioral experiments to look into behavioral changes in the cognitive functions of animals, leveraging virtually all available means of research in the field of modern biology.

 

One of its primary long-term project goals is to address diseases associated with brain functions. For instance, autism spectrum disorder (ASD), in many cases, is attributable to genetic mutations or DNA issues. Recently, the Lab has demonstrated that the hot spots of de novo mutations that lead to ASD are located in the DNA sites responsible for regulating gene expressions. This raises hope for the idea that repairing these sites may offer a solution to treating such brain disorders in the future.

Visit Other Labs

    Materials Mechanics Lab
    Advanced Electron Microscopy<br> & Functional Imaging Lab
    Innovative Device Engineering and Application (IDEA) Lab
    Logistics Lab
    Pohang Accelerator Laboratory
    Laboratory for Electrode Material Property
    Laboratory for High Energy Plasmas
    Analog IC Systems Lab
    Extreme Mechanics Lab
    Neuro-Epigenetics (NEPI) Lab
    Machine Learning Lab
    Clean Steel Lab
    Structural Nano Metals & Processing Lab
    MARCH Lab
    Wireless Communications and<br> Sensing Research Lab
    Computational Catalysis and<br> Emerging Materials Lab
    Flexible Electronics Group
    Thermal Hydraulics & Energy System Lab
    Computer Vision Lab
    Embedded Processor & Intelligent Computing (EPIC) Lab
    Smart Materials & Sensors Lab
    Climate System Lab
    Technology Enablement of<br> Advanced MOS structure
    Intelligent radar system<br> and signal processing lab
    Single-molecule biophysics lab
    Financial Investment & Risk Management Lab
    Interaction Laboratory
    Laboratory for Biological, Biomimetic,<br> Eco-friendly Materials
    Factory Intelligence lab
    Cellular Immunology Lab
    Analytics & Information Management Lab
    Nanoscale Photonics & Integrated Manufacturing Lab
    Biofabrication & translational medicine lab
    Quantum Nano-electronics lab
    Climate Change Research Lab
    Polymer-based Energy Materials Lab
    Molecular Biotechnology Lab
    Nanostructured Energy Materials Lab
    Organic Printed Electronics Lab
    Oxide & Quantum Materials Lab
    Bio Optics and Acoustics Lab
    Computational Metallurgy Lab
    CAD & SoC Design Lab
    X-ray Scattering & Spectroscopy Lab
    Computing and Control Engineering Lab
    Center for Nanospace-confined<br> Chemical Reactions
    Femtosecond Diffraction &<br> Imaging Science Lab
    Structural Bioinformatics Lab
    Chemical Cellomics Lab
    Applied Mathematics and Mining Lab
    Development Signaling<br>Network Lab
    Biomedical<br>Nanomaterials Lab
    Hazardous and Extreme<br>Environment Robotics Lab