Research

국제전문학술지

• Cellcell communication networkbased interpretable machine learning predicts cancer patient response to immune checkpoint inhibitors, Science Advances, , 10, - (2024 )
• OASIS portable Userfriendly offline suite for secure survival analysis, Molecules and Cells, , 47, 100011- (2024 )
• Heterogeneous osteoimmune profiles via singlecell transcriptomics in osteoporotic patients who fail bisphosphonate treatment, Proceedings of the National Academy of Sciences of the United States of America, , 121, - (2024 )
• A dietary commensal microbe enhances antitumor immunity by activating tumor macrophages to sequester iron, Nature Immunology, , 25, 790-801 (2024 )
• expHRD an individualized transcriptomebased prediction model for homologous recombination deficiency assessment in cancer, BMC Bioinformatics, , 25, - (2024 )
• Development of bioinformatics and multiomics analyses in organoids, BMB REPORTS, , 56, 43-48 (2023 )
• Identification of potential key variants in mandibular premolar hypodontia through wholeexome sequencing, Frontiers in Genetics, , 14, - (2023 )
• An evolutionbased machine learning to identify cancer typespecific driver mutations, BRIEFINGS IN BIOINFORMATICS, , 24, - (2023 )
• Drug approval prediction based on the discrepancy in gene perturbation effects between cells and humans, EBIOMEDICINE, , 94, - (2023 )
• Information about immune cell proportions and tumor stage improves the prediction of recurrence in patients with colorectal cancer, Patterns, , 4, - (2023 )
• Identification of novel candidate genes associated with nonsyndromic tooth agenesis in Mongolian families, Clinical Oral Investigations, , 28, - (2023 )
• Evolutionary rewiring of regulatory networks contributes to phenotypic differences between human and mouse orthologous genes, Nucleic Acids Research, , 50, 1849-1863 (2022 )
• Networkbased machine learning approach to predict immunotherapy response in cancer patients, Nature Communications, , 13, - (2022 )
• Enzyme activity engineering based on sequence coevolution analysis, METABOLIC ENGINEERING, , 74, 49-60 (2022 )
• Deconvolution of bulk tumors into distinct immune cell states predicts colorectal cancer recurrence, ISCIENCE, , 25, - (2022 )
• The implication of holocytochrome c synthase mutation in Korean familial hypoplastic amelogenesis imperfecta, Clinical Oral Investigations, , 26, 4487-4498 (2022 )
• Phylogenetic analysis of ABCG subfamily proteins in plants functional clustering and coevolution with ABCGs of pathogens, Physiologia Plantarum, , 172, 1422-1438 (2021 )
• MON2 a Golgi protein mediates autophagydependent longevity in Caenorhabditis elegans, Science Advances, , 7, - (2021 )
• Capicua restricts cancer stem celllike properties in breast cancer cells, Oncogene, , , - (2020 )
• Domainmediated interactions for protein subfamily identification, Scientific Reports, , 10, 264- (2020 )
• Capicua suppresses colorectal cancer progression via repression of ETV4 expression, Cancer Cell International, , 20, - (2020 )
• Singlecell RNA sequencing identifies shared differentiation paths of mouse thymic innate T cells, Nature Communications, , 11, - (2020 )
• Networkbased machine learning in colorectal and bladder organoid models predicts anticancer drug efficacy in patients, NATURE COMMUNICATIONS, , 11, - (2020 )
• Creation of bladder assembloids mimicking tissue regeneration and cancer, NATURE, , 588, 664-+ (2020 )
• Erratum to “Tetrahydrobiopterin enhances mitochondrial biogenesis and cardiac contractility via stimulation of PGC1α signaling” Biochimica et Biophysica Acta BBA Molecular Basis of Disease 2019 186511 S0925443919302418 101016jbbadis2019, Biochimica et Biophysica Acta Molecular Basis of Disease, , 1866, - (2020 )
• Evolutionary coupling analysis identifies the impact of diseaseassociated variants at lessconserved sites, NUCLEIC ACIDS RESEARCH, , 47, e94- (2019 )
• Exomic and transcriptomic alterations of hereditary gingival fibromatosis, ORAL DISEASES, , 25, 1374-1383 (2019 )
• Epigenetic regulation of mammalian Hedgehog signaling to the stroma determines the molecular subtype of bladder cancer, ELIFE, , 8, - (2019 )
• Tetrahydrobiopterin enhances mitochondrial biogenesis and cardiac contractility via stimulation of PGC1 alpha signaling, BIOCHIMICA ET BIOPHYSICA ACTAMOLECULAR BASIS OF DISEASE, , 1865, - (2019 )
• Link clustering explains noncentral and contextually essential genes in protein interaction networks, SCIENTIFIC REPORTS, , 9, - (2019 )
• Variants at potential loci associated with Sjogrens syndrome in Koreans A genetic association study, CLINICAL IMMUNOLOGY, , 207, 79-86 (2019 )
• KIN4MAST kinase promotes PTENmediated longevity of Caenorhabditis elegans via binding through a PDZ domain, AGING CELL, , 18, - (2019 )
• Phylogenetic analysis of ABCG subfamily proteins in plants: functional clustering and coevolution with ABCGs of pathogens, Physiologia Plantarum, , , - (2019 )
• Capicua suppresses hepatocellular carcinoma progression by controlling ETV4MMP1 axis, HEPATOLOGY, , 67, 2287-2301 (2018 )
• Head formation requires Dishevelled degradation that is mediated by March2 in concert with Dapper1, Development Cambridge, , 145, - (2018 )
• Divergence of Noncoding Regulatory Elements Explains GenePhenotype Differences between Human and Mouse Orthologous Genes, MOLECULAR BIOLOGY AND EVOLUTION, , 35, 1653-1667 (2018 )
• The mechanistic insight of a specific interaction between 15dProstaglandinJ2 and eIF4A suggests an evolutionary conserved role across species, Biology Open, , 7, - (2018 )
• Genetic analysis of hereditary gingival fibromatosis using whole exome sequencing and bioinformatics, Oral Diseases, , 23, 102-19 (2017 )
• Genetic alterations in mesiodens as revealed by targeted NGS and gene cooccurrence network analysis, ORAL DISEASES, , 23, 966-972 (2017 )
• Energy metabolism and wholeexome sequencingbased analysis of Sasang constitution a pilot study, Integrative Medicine Research, , 6, 165-178 (2017 )
• March2 is required for Xenopus head organizer formation by antagonizing Wnt signaling pathway, MECHANISMS OF DEVELOPMENT, , 145, S63-S63 (2017 )
• Spread of Mutant Middle East Respiratory Syndrome Coronavirus with Reduced Affinity to Human CD26 during the South Korean Outbreak, MBIO, , 7, - (2016 )
• OASIS 2 online application for survival analysis 2 with features for the analysis of maximal lifespan and healthspan in aging research, Oncotarget, , 7, 56147-56152 (2016 )
• Genetic analysis of hereditary gingival fibromatosis using whole exome sequencing and bioinformatics, Oral Diseases, , , - (2016 )
• Constitutive activation of T cells by γ2herpesviral GPCR through the interaction with cellular CXCR4, Biochimica et Biophysica Acta BBA Molecular Cell Research, , , - (2016 )
• OASIS 2: online application for survival analysis 2 with features for the analysis of maximal lifespan and healthspan in aging research, ONCOTARGET, , 7, 56147-56152 (2016 )
• Genetic Investigation of BisphosphonateRelated Osteonecrosis of Jaw BRONJ via Whole Exome Sequencing and Bioinformatics, PLOS ONE, , 10, E0118084- (2015 )
• Metazoans evolved by taking domains from soluble proteins to expand intercellular communication network, Scientific Reports, , 5, - (2015 )
• Network Modules of the CrossSpecies GenotypePhenotype Map Reflect the Clinical Severity of Human Diseases, PLOS ONE, , 10, E0136300- (2015 )
• RNA helicase HEL1 promotes longevity by specifically activating DAF16FOXO transcription factor signaling in Caenorhabditis elegans, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, , 112, E4246-E4255 (2015 )
• Identification of cancertypespecific modules comprised of cancertypespecific variants through phenotype similarity between cancer types, PROTEIN SCIENCE, , 24, 266-266 (2015 )
• A comprehensive protein domain analysis to map cancertypespecific somatic mutations, PROTEIN SCIENCE, , 24, 265-266 (2015 )
• Identification of transient protein complexes by using intrinsic disorder and network topology, PROTEIN SCIENCE, , 24, 258-259 (2015 )
• Computational Design of Binding Proteins to EGFR Domain II, PLOS ONE, , 9, - (2014 )
• Predictive combinatorial design of mRNA translation initiation regions for systematic optimization of gene expression levels, SCIENTIFIC REPORTS, , 4, - (2014 )
• Linear MotifMediated Interactions Have Contributed to the Evolution of Modularity in Complex Protein Interaction Networks, PLOS COMPUTATIONAL BIOLOGY, , 10, E1003881- (2014 )
• Feedback regulation via AMPK and HIF1 mediates ROSdependent longevity in Caenorhabditis elegans, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, , 111, E4458-E4467 (2014 )
• Investigation of Pathogenic Genes in PeriImplantitis from Implant Clustering Failure Patients A WholeExome Sequencing Pilot Study, PLOS ONE, , 9, - (2014 )
• Pyrilamine inhibits nicotineinduced catecholamine secretion, NEUROCHEMISTRY INTERNATIONAL, , 74, 42-45 (2014 )
• Domain Exchange Between Membrane And Soluble Proteins Contributes To Expand Intercellular Communication Network, Protein Science, , 23, 257-257 (2014 )
• Predictive design of mRNA translation initiation region to control prokaryotic translation efficiency, METABOLIC ENGINEERING, , 15, 67-74 (2013 )
• Discovery of Cellular Proteins Required for the Early Steps of HCV Infection Using Integrative Genomics, PLOS ONE, , 8, - (2013 )
• Rampant Exchange of the Structure and Function of Extramembrane Domains between Membrane and Water Soluble Proteins, PLOS COMPUTATIONAL BIOLOGY, , 9, E1002997- (2013 )
• Spatial and functional organization of mitochondrial protein network, SCIENTIFIC REPORTS, , 3, 1403- (2013 )
• A novel role for Gadd45 alpha in base excision repair Modulation of APE1 activity by the direct interaction of Gadd45 alpha with PCNA, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, , 434, 185-190 (2013 )
• Protein design by fusion implications for protein structure prediction and evolution, Acta Crystallographica Section D, , 69, 2451-2460 (2013 )
• Rewiring of PDZ domainligand interaction network contributed to eukaryotic evolution, PLOS GENETICS, , 8, -E1002510 (2012 )
• The protein interaction network of extracellular vesicles derived from human colorectal cancer cells, JOURNAL OF PROTEOME RESEARCH, , 11, 1144-1151 (2012 )
• Role of BI1 TEGTmediated ERK12 activation in mitochondriamediated apoptosis and splenomegaly in BI1 transgenic mice, Biochimica et Biophysica Acta Molecular Cell Research, , 1823, 876-888 (2012 )
• PDZ Domaincontaining 1 PDZK1 Protein Regulates Phospholipase Cbeta 3 PLCbeta 3specific Activation of Somatostatin by Forming a Ternary Complex with PLCbeta 3 and Somatostatin Receptors, JOURNAL OF BIOLOGICAL CHEMISTRY, , 287, 21012-21024 (2012 )
• Rational Engineering of Enzyme Allosteric Regulation through Sequence Evolution Analysis, PLOS COMPUTATIONAL BIOLOGY, , 8, E1002612-E1002612 (2012 )
• Network rewiring is an important mechanism of gene essentiality change, SCIENTIFIC REPORTS, , 2, - (2012 )
• Phenotypic characterization of peripheral T cells and their dynamics in scrub typhus patients, PLOS NEGLECTED TROPICAL DISEASES, , 6, - (2012 )
• Structural differences between thermophilic and mesophilic membrane proteins, PROTEIN SCIENCE, , 21, 1746-1753 (2012 )
• Evolutionary history of human disease genes reveals phenotypic connections and comorbidity among genetic diseases, SCIENTIFIC REPORTS, , 2, - (2012 )
• Both the Hydrophobicity and a Positively Charged Region Flanking the CTerminal Region of the Transmembrane Domain of SignalAnchored Proteins Play Critical Roles in Determining Their Targeting, PLANT CELL, , 23, 1588-1607 (2011 )
• Protein localization as a principal feature of the etiology and comorbidity of genetic diseases, MOLECULAR SYSTEMS BIOLOGY, , 7, - (2011 )
• Network Clustering Revealed the Systemic Alterations of Mitochondrial Protein Expression, PLOS COMPUTATIONAL BIOLOGY, , 7, - (2011 )
• OASIS Online Application for the Survival Analysis of Lifespan Assays Performed in Aging Research, PLOS ONE, , 6, - (2011 )
• Molecular Evolution of Protein Conformational Changes Revealed by a Network of Evolutionarily Coupled Residues, MOLECULAR BIOLOGY AND EVOLUTION, , 28, 2675-2685 (2011 )
• A multifunctional core-shell nanoparticle for dendritic cell-based cancer immunotherapy, NATURE NANOTECHNOLOGY, , 6, 675-682 (2011 )
• Global Sequence Homology Detection Using Word Conservation Probability, Interdisciplinary Bio Central, , 3, 1-9 (2011 )
• A multifunctional coreshell nanoparticle for dendritic cellbased cancer immunotherapy, NATURE NANOTECHNOLOGY, , 6, 675-682 (2011 )
• Bax Inhibitor 1 Increases Cell Adhesion through Actin Polymerization Involvement of Calcium and Actin Binding, MOLECULAR AND CELLULAR BIOLOGY, , 30, 1800-1813 (2010 )
• Global gene expression profile of Orientia tsutsugamushi, PROTEOMICS, , 10, 1699-1715 (2010 )
• ConPlex: a server for the evolutionary conservation analysis of protein complex structures., NUCLEIC ACIDS RESEARCH, , 38, W450-W456 (2010 )
• ConPlex a server for the evolutionary conservation analysis of protein complex structures, NUCLEIC ACIDS RESEARCH, , 38, W450-W456 (2010 )
• Changes in Hepatic Gene Expression upon Oral Administration of TaurineConjugated Ursodeoxycholic Acid in obob Mice, PLOS ONE, , 5, - (2010 )
• CONSTRUCTION OF FUNCTIONAL INTERACTION NETWORKS THROUGH CONSENSUS LOCALIZATION PREDICTIONS OF THE HUMAN PROTEOME, JOURNAL OF PROTEOME RESEARCH, , 8, 3367-3376 (2009 )
• Integration of Evolutionary Features for the Identification of Functionally Important Residues in Major Facilitator Superfamily Transporters, PLOS COMPUTATIONAL BIOLOGY, , 5, E1000522-E1000522 (2009 )
• Evolutionary conservation in multiple faces of protein interaction, PROTEINSSTRUCTURE FUNCTION AND BIOINFORMATICS, , 77, 14-25 (2009 )
• Bioinformatic approaches for the structure and function of membrane proteins, BMB REPORTS, , 42, 697-704 (2009 )
• Dimerization of the transmembrane domain of amyloid precursor proteins and familial Alzheimers disease mutants, BMC NEUROSCIENCE, , 9, - (2008 )
• Common occurrence of internal repeat symmetry in membrane proteins, PROTEINSSTRUCTURE FUNCTION AND BIOINFORMATICS, , 71, 68-80 (2008 )
• Transmembrane helix uniformity examined by spectral mapping of torsion angles, STRUCTURE, , 16, 787-797 (2008 )
• Functional analysis of dicer2 missense mutations in the siRNA pathway of Drosophila, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, , 371, 525-530 (2008 )
• Expression of the novel wheat gene TM20 confers enhanced cadmium tolerance to bakers yeast, JOURNAL OF BIOLOGICAL CHEMISTRY, , 283, 15893-15902 (2008 )
• Bax inhibitor1 is a pHdependent regulator of Ca2 channel activity in the endoplasmic reticulum, JOURNAL OF BIOLOGICAL CHEMISTRY, , 283, 15946-15955 (2008 )
• Genomebased construction of the metabolic pathways of Orientia tsutsugamushi and comparative analysis within the Rickettsiales order, COMPARATIVE AND FUNCTIONAL GENOMICS, , , - (2008 )
• Arabidopsis nuclearencoded plastid transit peptides contain multiple sequence subgroups with distinctive chloroplasttargeting sequence motifs, PLANT CELL, , 20, 1603-1622 (2008 )
• Role of Amphipathic Helix of a Herpesviral Protein in Membrane Deformation and T Cell Receptor Downregulation, PLOS PATHOGENS, , 4, - (2008 )
• THE SYNTHESIS AND HYDRAULIC PROPERTIES OF CALCIUM SULFO ALUMINATE(CSA) DERIVED FROM SECONDARY REFINING SLAG, JOURNAL OF THE KOREAN INSTITUTE OF METALS AND MATERIALS, , 46, 437-442 (2008 )
• Janus model of the NaKATPase betasubunit transmembrane domain Distinct faces mediate alphabeta assembly and betabeta homooligomerization, JOURNAL OF MOLECULAR BIOLOGY, , 365, 706-714 (2007 )
• Engineering a de novo internal disulfide bridge to improve the thermal stability of xylanase from Bacillus stearothermophilus No 236, JOURNAL OF BIOTECHNOLOGY, , 127, 300-309 (2007 )
• Association and functional relevance of E237G a polymorphism of the highaffinity immunoglobulin Ereceptor beta chain gene to airway hyperresponsiveness, CLINICAL AND EXPERIMENTAL ALLERGY, , 37, 592-598 (2007 )
• Transmembrane domain of myelin protein zero can form dimers Possible implications for myelin construction, BIOCHEMISTRY, , 46, 12164-12173 (2007 )
• Functional characterization of sequence motifs in the transit peptide of Arabidopsis small subunit of Rubisco, PLANT PHYSIOLOGY, , 140, 466-483 (2006 )
• A limited universe of membrane protein families and folds, PROTEIN SCIENCE, , 15, 1723-1734 (2006 )
• Selfassociation of the transmembrane domain of an anthrax toxin receptor, JOURNAL OF MOLECULAR BIOLOGY, , 360, 145-156 (2006 )
• Pivotal role of the glycinerich TM3 helix in gating the MscS mechanosensitive channel, NATURE STRUCTURAL MOLECULAR BIOLOGY, , 12, 113-119 (2005 )
• Transmembrane domain helix packing stabilizes integrin aIIb beta 3 in the low affinity state, JOURNAL OF BIOLOGICAL CHEMISTRY, , 280, 7294-7300 (2005 )
• Transmembrane glycine zippers Physiological and pathological roles in membrane proteins, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, , 102, 14278-14283 (2005 )
• 2D SOLID STATE NMR SPECTRAL SIMULATION OF 310 ALPHA AND PIHELICES, JOURNAL OF MAGNETIC RESONANCE, , 168, 187-193 (2004 )
• A MODEL OF THE CLOSED FORM OF THE NICOTINIC ACETYLCHOLINE RECEPTOR M2 CHANNEL PORE, BIOPHYSICAL JOURNAL, , 87, 792-799 (2004 )
• Membrane channel structure of Helicobacter pylori vacuolating toxin Role of multiple GXXXG motifs in cylindrical channels, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, , 101, 5988-5991 (2004 )
• SNORKELING PREFERENCES FOSTER AN AMINO ACID COMPOSITION BIAS IN TRANSMEMBRANE HELICES, JOURNAL OF MOLECULAR BIOLOGY, , 339, 471-479 (2004 )
• The affinity of GXXXG motifs in transmembrane helixhelix interactions is modulated by longrange communication, JOURNAL OF BIOLOGICAL CHEMISTRY, , 279, 16591-16597 (2004 )
• Dynamical localization and partialbarrier localization in the Paul trap, PHYSICAL REVIEW E, , 61, 5124-5128 (2000 )

학회발표

• SCANEER Enzyme Activity Engineering based on Sequence Evolution Analysis, , 0, 0, - (2023)
• Application of Sequence CoEvolution and Structural Analysis for the Enhancing of Enzyme Activity, , 0, 0, - (2023)
• Enzyme Activity Engineering based on Sequence Evolution Analysis, , 0, 0, - (2023)
• Application of Sequence CoEvolution and Structural Analysis for the Enhancing of Enzyme Activity, , 0, 0, - (2023)
• Networkbased machinelearning to predict drug efficacy in cancer patients, , 0, 0, - (2022)
• Network biology approaches to predict anticancer drug response using organoid models, , 0, 0, - (2022)
• Network biology approaches to understand patients’ response to cancer treatments, , 0, 0, - (2021)
• Networkbased approaches to discover biomarkers of rare diseases based on GWAS studies, , 0, 0, - (2021)
• 정밀의료를 위한 환자 의료 데이터와 멀티오믹스 데이터의 생물정보학 기반 통합 전략, , 0, 0, - (2021)
• Generation of forebrain assembloids for modeling development of human schizophrenic brain, , 0, 0, - (2020)
• Regulatory network rewiring explains the phenotypic evolution between human and model organism, Wellcome Trust Genome Conference Series Evolutionary Systems Biology, 0, 0, - (2020)
• Visible machine learning approach to predict anticancer drug efficacy in cancer patients using organoid models, Wellcome Trust Genome Institute Conference Evolutionary Systems Biology, 0, 0, - (2020)
• Identification of cancer typespecific driver mutations using sequence coevolution analysis, Wellcome Trust Genome Institute Conference Wellcome Trust Genome Institute, 0, 0, - (2020)
• Evolution of functional modules and regulatory networks Understanding genotypephenotype relationship, Asian Bioinformatics Consortium ABC Symposium, 0, 0, - (2019)
• A systematic genephenotype comparison between human and mouse to find accurate phenologs, The 16th KoreaJapanChina Bioinformatics Symposium, 0, 0, - (2018)
• Identification of druggable PPIs using domainmediated interaction interfaces, 26th Conference on Intelligent Systems for Molecular Biology, 0, 0, - (2018)
• Predicting mutational impact of diseaseassociated variants based on the network of evolutionary coupled residues, 26th Conference on Intelligent Systems for Molecular Biology, 0, 0, - (2018)
• Transcriptomic changes in network partners of orthologous genes represent phenotypic differences between species, 26th Conference on Intelligent Systems for Molecular Biology, 0, 0, - (2018)
• Identification of cancer essential genes through integration of cellline specific network, 26th Conference on Intelligent Systems for Molecular Biology, 0, 0, - (2018)
• Biological functions rather than individual genes can explain the phenotypic differences observed between human and mouse orthologous genes, 10th Annual RECOMBISCB Confernce on Regulatory Systems Genomics, 0, 0, - (2017)
• Identification of biomarkers and prediction of survival based on exome sequencing of the mouse model of aggressive bladder cancer, 10th Annual RECOMBISCB Confernce on Regulatory Systems Genomics, 0, 0, - (2017)
• A Golgi protein MON2 mediates longevity conferred by reduced mitochondrial respiration in C elegans , , 0, 0, - (2017)
• KIN4MAST kinase binds DAF18PTEN through its PDZ domain and contributes to the longevity of daf2insulinIGF1 receptor mutants , , 0, 0, - (2017)
• KIN4protein kinase influences insulinIGF1 signalingmediated longevity via interacting with DAF18PTEN in C elegans , , 0, 0, - (2017)
• Predicting the functional impact of protein mutations using coevolutionary signals, INTERNATIONAL CONFERENCE ON SYSTEMS BIOLOGY 2016, 0, 0, - (2016)
• Types of domain mediated interaction explain gentypephenotype relationships, INTERNATIONAL CONFERENCE ON SYSTEMS BIOLOGY 2016, 0, 0, - (2016)
• Network evolution and phenotype changes between species, INTERNATIONAL CONFERENCE ON SYSTEMS BIOLOGY 2016, 0, 0, - (2016)
• Popularity and similarity in network evolution explain the architecture of coreattachemnt in protein complexes, INTERNATIONAL SCHOOL AND CONFERENCE ON NETWORK SCIENCE 2016, 0, 0, - (2016)
• Network evolution and understanding human genephenotype relationship, INTERNATIONAL SCHOOL AND CONFERENCE ON NETWORK SCIENCE 2016, 0, 0, - (2016)
• Phenotype role of domain mediated interactions through community detection on the structural interaction network, INTERNATIONAL SCHOOL AND CONFERENCE ON NETWORK SCIENCE 2016, 0, 0, - (2016)
• Identification of transient protein complexes by using intrinsic disorder and network topology, , 0, 0, - (2015)
• Identification of cancertypespecific modules comprised of cancertypespecific variants through phenotype similarity between cancer types, , 0, 0, - (2015)
• A comprehensive protein domain analysis to map cancertypespecific somatic mutations, , 0, 0, - (2015)
• Protein complexes differ in the density and the modularity of proteinprotein interactions to achieve, , 0, 0, - (2015)
• Weak linear motifmediated interactions contribute to the rearrangement of modular architecture in complex protein interaction networks, , 0, 0, - (2014)
• Gene essentiality on model organism explains clinical severity of human genetic disorders, , 0, 0, - (2014)
• Domain exchange between membrane and soluble proteins contributes to expand intercellular communication network, , 0, 0, - (2014)
• Analysis of protein domains and gene essentiality, , 0, 0, - (2014)
• Domain exchange between membrane and soluble proteins contributes to metazoan evolution, , 0, 0, - (2013)
• Improving module identification in proteinprotein interaction networks by using interaction strengths, , 0, 0, - (2013)
• Modular architecture of gene essentiality reveals clinical severity of human genetic diseases, , 0, 0, - (2013)
• Network Evolution and Gene Essentiality Changes, , 0, 0, - (2013)
• Fold Space and Function Annotation of Membrane Proteins, , 0, 0, - (2013)
• Analysis of shared structure and function between membrane and watersoluble proteins for drug design, , 0, 0, - (2012)
• Analysis of interaction strengths and global architecture in proteinprotein interaction networks, , 0, 0, - (2012)
• Multipath in protein interaction network improved the understanding of the comorbidity of genetic diseases, , 0, 0, - (2012)
• Network medicine to predict drug side effectsFunctional diversity of membrane proteins is mediated by dynamic rewiring of protein interactions, , 0, 0, - (2012)
• Global Sequence Homology Detection Using Word Conservation Probability, , 0, 0, - (2011)
• Comparative network analysis reveals the mechanism of gene essentiality changes, , 0, 0, - (2011)
• Evolutionary connections of disease modules implicate in the comorbidity, , 0, 0, - (2011)
• Evolution of domainlinear motif interactions shapes the modular architecture of proteinprotein interaction networks, , 0, 0, - (2011)
• Connection patterns in proteinprotein interaction network reveal the phenotypic relationships among human diseases, , 0, 0, - (2011)
• Ehealth for disease prognosis Connection patterns in proteinprotein interaction network reveal phenotype similarity and comorbidity of genetic diseases, , 0, 0, - (2011)
• Ehealth and network medicine Network position can identify mitochondrial disease genes, , 0, 0, - (2011)
• Protein Localization as a principal feature of comorbidity, , 0, 0, - (2011)
• Comparative genomics between yeast and mouse reveals the etiology of genetic diseases, , 0, 0, - (2011)
• Network medicine to predict drug side effects Rewiring of proteinprotein interaction network of plasma membrane proteins explains drug side effects, , 0, 0, - (2011)
• Structural property of proteinprotein interactions explains functional associations at the molecular and phenotypic levels, , 0, 0, - (2011)
• Ehealth and drug target discovery Analysis of fold space of membrane proteins to find the template structures for drug target discovery, , 0, 0, - (2011)
• Membrane proteins share fold space with soluble proteins to expand their functional diversity during evolution, , 0, 0, - (2011)
• Tissue Specific Interactions of Plasma Membrane Proteins as the Mechanism of Functional Diversity, , 0, 0, - (2010)
• Protein conformational changes are derived from the network of evolutionarily coupled residues, , 0, 0, - (2010)
• Systematic analysis of human PDZ domainligand interaction network and their localization, , 0, 0, - (2010)
• The implications of protein subcellular localization for disease profiling, , 0, 0, - (2010)
• Systematic analysis of mitochondrial proteins involved in the communication to the cell, , 0, 0, - (2010)
• The important role of protein subcellular localization in disease profiling, , 0, 0, - (2010)
• Understanding the mitochondrial proteins involved in the communication to the cell through network biology, , 0, 0, - (2010)
• Comprehensive analysis of human PDZ domainligand interaction network, , 0, 0, - (2010)
• New insight into the fold space of membrane proteins revealed by structural comparison with soluble proteins, , 0, 0, - (2010)
• Tissue specific expression of plasma membrane proteins and their functional diversity, , 0, 0, - (2010)
• Insights into protein flexibility The relationship between evolutionarily coupled residues and conformational changes, , 0, 0, - (2010)
• The importance of protein subcellular localization for disease profiling, , 0, 0, - (2010)
• Evolutionary analysis of conformational changes in allosteric proteins, , 0, 0, - (2010)
• Evolution of protein dynamics Role of residue interaction networks in protein allostery, , 0, 0, - (2009)
• Quantitative interaction prediction revealed the genomewide selectivity preferences of human PDZ domains, , 0, 0, - (2009)
• Identification of functional residues in Major Facilitator Superfamily MFS transporters using evolutionary features, , 0, 0, - (2009)
• Identification of eukaryotespecific mitochondrial proteome through data integration and phylogenetic profiling, , 0, 0, - (2009)
• Functional and evolutionary relationship between membrane and soluble proteins, , 0, 0, - (2009)
• Bioinformatic studies of protein sequence structure and function, , 0, 0, - (2009)
• Intrinsically unstructured Cterminal regions of transmembrane PDZ ligands play an important role in clustering scaffold proteins, , 0, 0, - (2009)
• Analysis of eukaryotespecific mitochondrial protein networks through data integration and phylogenetic profiling, , 0, 0, - (2009)
• Genomewide selectivity preferences of human PDZ domainligand interactions, , 0, 0, - (2009)
• Identification of eukaryotespecific mitochondrial proteome through data integration and phylogenetic profiling, , 0, 0, - (2009)
• Functional and evolutionary relationship between membrane and soluble proteins, , 0, 0, - (2009)
• Assessing systems properties of human mitochondria through a quantitative proteomics analysis, , 0, 0, - (2009)
• A new systematic approach to identify functions of human extracellular proteins using yeast, , 0, 0, - (2009)
• Rational design of binding determinant specific nonantibody protein scaffolds EGFR inhibitors with novel mechanism of action, , 0, 0, - (2009)
• Intrinsically unstructured Cterminal regions of transmembrane PDZ ligands play an important role in clustering scaffold proteins, , 0, 0, - (2009)
• Evolutionary conservation in multiple face of protein interaction, , 0, 0, - (2009)
• Protein interface design to generate novel binder proteins, The 6th Proteome Biophysics workshop, 0, 0, - (2008)
• Evolutionary conservation in multiple faces of protein interaction, 2008 YBRIKIAS international symposium of protein structure and function, 0, 0, - (2008)
• Locally fluctuating ligandbinding residues transfer ligand binding signals to distal sites via coevolved pathway, 2008 YBRIKIAS international symposium of protein structure and function, 0, 0, - (2008)
• Quantitative interation prediction revealed the genomewide selectivity preferences of human PDZ domains, 2008 YBRIKIAS international symposium of protein structure and function, 0, 0, - (2008)
• Largescale Analysis of Protein Complexes Reveals Evolutionary Conservation in Multiple faces of Protein interaction, The 9th International Congress on Cell Biology, 0, 0, - (2008)
• Locally fluctuating ligandbinding residues transfer ligand binding signals to distal sites via coevolved pathway, , 0, 0, - (2008)
• Quantitative interaction prediction revealed the genomewide selectivity preferences of human PDZ domains, , 0, 0, - (2008)
• Largescale Analysis of Protein Complexes Reveals Evolutionary Conservation in Multiple faces of Protein interaction, , 0, 0, - (2008)
• Integrative proteomics analysis of human mitochondrial protein functional network in normal and dysfunctional states, The 22nd symposium of the protein society, 0, 0, - (2008)
• Systematic Integration of Proteomics and Bioinformatics Reveals the Evolutionary Modularity of Human Mitochondrial Protein Functional Network, From Bench to Clinic Mitochondria and Metabolic Diseases, 0, 0, - (2008)
• Structural Bioinformatics Studies of ProteinProtein interaction network, 2008 Korean Biophysical Society Meeting, 0, 0, - (2008)
• A comparative mitochondrial proteomics of human 143B TK osteosarcoma cells upon mitochondrial DNA depletion using ICAT and LCMSMS, 8th International Proteomics Conference, 0, 0, - (2008)
• Assessing systems property of human mitochondrial protein functional network by using integrative proteomics and bioinformatics, 8th international Proteomics Conference, 0, 0, - (2008)
• Largescale analysis of protein complexes reveals evolutionary conservation in multiple faces of protein interaction, The 65th KSBMB Annual Meeting in 2008, 0, 0, - (2008)
• Assessing systems properties of human protein functional network by an integrated proteomics and bioinformatics approach, The 25th Korean sociey for cell biology symposium, 0, 0, - (2008)
• Structure Comparison by use of Geometric Hashing, The 7th Protein Folding School, 0, 0, - (2008)
• Prediction of functional residues in major facilitator superfamily transporters using integrated evolutionary features, The Sixth Asia Pacific Bioinformatics Conference 2008, 0, 0, - (2008)
• Structural bioinformatics of membrane proteins and proteinprotein interactions, The 4th Molecular Computation Initiative Workshop, 0, 0, - (2007)
• Bioinformatics approaches of Mitochondrial ion channel discovery, 2nd symposium of Korean society for Mitochondrial Research and Medicine, 0, 0, - (2007)
• Discovery of novel mitochondrial membrane proteins by systematic data integration, 8th International Conference of Korean Society for Bioinformatics, 0, 0, - (2007)
• Finding amino acid patterns in protein localization, The 8th International Conference of Korean Society for Bioinformatics, 0, 0, - (2007)
• Identification of ligand binding site in eukaryotic translation initiation factor 4A by docking study, 8th International Conference of Korean Society for Bioinformatics, 0, 0, - (2007)
• Identification of the functinal network components in tumor derived microvesicles, 8th International Conference of Korean Society for Bioinformatics, 0, 0, - (2007)
• Missing puzzles in current proteome researches the membrane protein functionomics, The 8th International Conference of Korean Society for Bioinformatics, 0, 0, - (2007)
• Reorganizing protein functional network based on the consensus localization prediction, 8th International Conference of Korean Society for Bioinformatics, 0, 0, - (2007)
• Specificity prediction of PDZ domain using machine learning technique, 8th International Conference of Korean Society for Bioinformatics, 0, 0, - (2007)
• Specificity prediction of PDZ domain using kernel based machine learning, IEEE international conference on Bioengineering Bioinformactics, 0, 0, - (2007)
• Prediction of membrane protein structures and functions by using bioinformatics, Protein Structure Interaction Stability and Function Workshop, 0, 0, - (2007)
• Detecting the ligand selectivity of subfamily proteins by using evolutionary conserved and functionally coevolved residues, European Symposium of the Protein Society, 0, 0, - (2007)
• Identification of functional residues in Major Facilitator Superfamily MFS transporters using evolutionary information, European Symposium of the Protein Society, 0, 0, - (2007)
• Structural Bioinformatics of membrane proteins and proteinprotein interactions, The 6th ChinaJapanKorea Bioinformatics training course, 0, 0, - (2007)
• Specificity prediction of PDZ domain using kernel based machine learning, The fifth aisa pacific bioinformatics conference, 0, 0, - (2007)
• Bioinformatics approach to study membrane protein structure and function, Current topics in biomedical sciences, 0, 0, - (2006)
• modeling membrane protein structure and function, The 7th international conference of Korean society for Bioinformatics, 0, 0, - (2006)
• Modeling structure and function of membrane proteins, 2006 Asia Pacific summer school on computational biology, 0, 0, - (2006)
• Internal sequence repeats and structural symmetry in membrane proteins, 50th Biophysical Society Annual Meeting, 0, 0, - (2006)
• Structural bioinformatics studies of membrane protein folding and functional mechanism, Membrane Protein Symposium, 0, 0, - (2006)
• Membrane protein structure and functional prediction, The 7th Northeastern Asia Symposium on Biotechnology, 0, 0, - (2005)
• Membrane protein structure prediction using symmetry information and clustering, The Fifth KIAS Conference on Protein Structure and Function, 0, 0, - (2005)
• Structural bioinformatics study of membrane proteins, New Trends in BioScience ""International symposium with KSMCB"", 0, 0, - (2005)
• Structural bioinformatics study on transmembrane signaling, Annual Meeting of Korean Society for Biochemistry and Molecular Biology, 0, 0, - (2005)
• Structural bioinformatics study on transmembrane signaling, Annual Meeting of Korean Society for Biochemistry and Molecular Biology, 0, 0, - (0000)
• Membrane protein structure and functional prediction, The 7th Northeastern Asia Symposium on Biotechnology, 0, 0, - (0000)
• Structural bioinformatics study of membrane proteins, New Trends in Bio-Science ""International symposium with KSMCB"", 0, 0, - (0000)
• Membrane protein structure prediction using symmetry information and clustering, The Fifth KIAS Conference on Protein Structure and Function, 0, 0, - (0000)
• Structural bioinformatics studies of membrane protein folding and functional mechanism, Membrane Protein Symposium, 0, 0, - (0000)
• Internal sequence repeats and structural symmetry in membrane proteins, 50th Biophysical Society Annual Meeting, 0, 0, - (0000)
• Modeling structure and function of membrane proteins, 2006 Asia Pacific summer school on computational biology, 0, 0, - (0000)
• modeling membrane protein structure and function, The 7th international conference of Korean society for Bioinformatics, 0, 0, - (0000)
• Bioinformatics approach to study membrane protein structure and function, Current topics in biomedical sciences, 0, 0, - (0000)
• Specificity prediction of PDZ domain using kernel based machine learning, The fifth aisa pacific bioinformatics conference, 0, 0, - (0000)
• Structural Bioinformatics of membrane proteins and protein-protein interactions, The 6th China-Japan-Korea Bioinformatics training course, 0, 0, - (0000)
• Detecting the ligand selectivity of sub-family proteins by using evolutionary conserved and functionally coevolved residues, European Symposium of the Protein Society, 0, 0, - (0000)
• Identification of functional residues in Major Facilitator Superfamily (MFS) transporters using evolutionary information, European Symposium of the Protein Society, 0, 0, - (0000)
• Prediction of membrane protein structures and functions by using bioinformatics, Protein Structure, Interaction, Stability and Function Workshop, 0, 0, - (0000)
• Specificity prediction of PDZ domain using kernel based machine learning, IEEE international conference on Bioengineering & Bioinformactics, 0, 0, - (0000)
• Discovery of novel mitochondrial membrane proteins by systematic data integration, 8th International Conference of Korean Society for Bioinformatics, 0, 0, - (0000)
• Finding amino acid patterns in protein localization, The 8th International Conference of Korean Society for Bioinformatics, 0, 0, - (0000)
• Identification of ligand binding site in eukaryotic translation initiation factor 4A by docking study, 8th International Conference of Korean Society for Bioinformatics, 0, 0, - (0000)
• Identification of the functinal network components in tumor derived microvesicles, 8th International Conference of Korean Society for Bioinformatics, 0, 0, - (0000)
• Missing puzzles in current proteome researches; the membrane protein functionomics, The 8th International Conference of Korean Society for Bioinformatics, 0, 0, - (0000)
• Reorganizing protein functional network based on the consensus localization prediction, 8th International Conference of Korean Society for Bioinformatics, 0, 0, - (0000)
• Specificity prediction of PDZ domain using machine learning technique, 8th International Conference of Korean Society for Bioinformatics, 0, 0, - (0000)
• Bioinformatics approaches of Mitochondrial ion channel discovery, 2nd symposium of Korean society for Mitochondrial Research and Medicine, 0, 0, - (0000)
• Structural bioinformatics of membrane proteins and protein-protein interactions, The 4th Molecular Computation Initiative Workshop, 0, 0, - (0000)
• Prediction of functional residues in major facilitator superfamily transporters using integrated evolutionary features, The Sixth Asia Pacific Bioinformatics Conference 2008, 0, 0, - (0000)
• Structure Comparison by use of Geometric Hashing, The 7th Protein Folding School, 0, 0, - (0000)
• Assessing systems properties of human protein functional network by an integrated proteomics and bioinformatics approach, The 25th Korean sociey for cell biology symposium, 0, 0, - (0000)
• Large-scale analysis of protein complexes reveals evolutionary conservation in multiple faces of protein interaction., The 65th KSBMB Annual Meeting in 2008, 0, 0, - (0000)
• A comparative mitochondrial proteomics of human 143B TK osteosarcoma cells upon mitochondrial DNA depletion using ICAT and LC/MS/MS, 8th International Proteomics Conference, 0, 0, - (0000)
• Assessing systems property of human mitochondrial protein functional network by using integrative proteomics and bioinformatics, 8th international Proteomics Conference, 0, 0, - (0000)
• Structural Bioinformatics Studies of Protein-Protein interaction network, 2008 Korean Biophysical Society Meeting, 0, 0, - (0000)
• Systematic Integration of Proteomics and Bioinformatics Reveals the Evolutionary Modularity of Human Mitochondrial Protein Functional Network., From Bench to Clinic : Mitochondria and Metabolic Diseases, 0, 0, - (0000)
• Integrative proteomics analysis of human mitochondrial protein functional network in normal and dysfunctional states, The 22nd symposium of the protein society, 0, 0, - (0000)
• Large-scale Analysis of Protein Complexes Reveals Evolutionary Conservation in Multiple faces of Protein interaction, The 9th International Congress on Cell Biology, 0, 0, - (0000)
• Evolutionary conservation in multiple faces of protein interaction, 2008 YBRI-KIAS international symposium of protein structure and function, 0, 0, - (0000)
• Locally fluctuating ligand-binding residues transfer ligand binding signals to distal sites via co-evolved pathway, 2008 YBRI-KIAS international symposium of protein structure and function, 0, 0, - (0000)
• Quantitative interation prediction revealed the genome-wide selectivity preferences of human PDZ domains, 2008 YBRI-KIAS international symposium of protein structure and function, 0, 0, - (0000)
• Protein interface design to generate novel binder proteins, The 6th Proteome Biophysics workshop, 0, 0, - (0000)