Research

International

• Cellcell communication networkbased interpretable machine learning predicts cancer patient response to immune checkpoint inhibitors, Science Advances, , 10, - (2024 )
• Probiotic Consortium Confers Synergistic AntiInflammatory Effects in Inflammatory Disorders, NUTRIENTS, , 16, - (2024 )
• A dietary commensal microbe enhances antitumor immunity by activating tumor macrophages to sequester iron, Nature Immunology, , 25, 790-801 (2024 )
• ETV5 promotes lupus pathogenesis and follicular helper T cell differentiation by inducing osteopontin expression, Proceedings of the National Academy of Sciences of the United States of America, , 121, - (2024 )
• Gut Microbiota Defines Functional Direction of Colonic Regulatory T Cells with Unique TCR Repertoires, Journal of Immunology, , 213, 886-897 (2024 )
• Glut3 promotes cellular OGlcNAcylation as a distinctive tumorsupportive feature in Treg cells, Cellular Molecular Immunology, , 21, 1474-1490 (2024 )
• IL2mediated modulation of small extracellular vesicles secretion and PDL1 expression a novel perspective for neutralizing immune suppression within cancer cells, Cancer Communications, , , - (2024 )
• The transcription factor Mef2d regulates BT synapse–dependent GCTFH differentiation and IL21–mediated humoral immunity, Science immunology, , 8, - (2023 )
• Forkhead box protein D2 suppresses colorectal cancer by reprogramming enhancer interactions, Nucleic Acids Research, , 51, 6143-6155 (2023 )
• Drug approval prediction based on the discrepancy in gene perturbation effects between cells and humans, EBIOMEDICINE, , 94, - (2023 )
• Exploring probiotic effector molecules and their mode of action in gutimmune interactions, FEMS MICROBIOLOGY REVIEWS, , 47, - (2023 )
• NFAT1 and NFκB regulates expression of the common γchain cytokine receptor in activated T cells, CELL COMMUNICATION AND SIGNALING, , 21, - (2023 )
• Microbial Components and Effector Molecules in T Helper Cell Differentiation and Function, Immune Network, , 23, - (2023 )
• TH1Treg ratio may be a marker of autism in children with immune dysfunction, Research in Autism Spectrum Disorders, , 101, - (2023 )
• NAMPT mitigates colitis severity by supporting redoxsensitive activation of phagocytosis in inflammatory macrophages, Redox Biology, , 50, - (2022 )
• Resolving the Mutually Exclusive Immune Responses of Chitosan with Nanomechanics and Immunological Assays, Advanced Healthcare Materials, , , - (2022 )
• T Helper 2Associated Immunity in the Pathogenesis of Systemic Lupus Erythematosus, Frontiers in Immunology, , 13, - (2022 )
• Signaling networks controlling ID and E protein activity in T cell differentiation and function, Frontiers in Immunology, , 13, 964581- (2022 )
• Networkbased machine learning approach to predict immunotherapy response in cancer patients, Nature Communications, , 13, - (2022 )
• ETS1 governs pathological tissueremodeling programs in diseaseassociated fibroblasts, Nature Immunology, , 23, 1330-1341 (2022 )
• Visualizing inflammation with an M1 macrophage selective probe via GLUT1 as the gating target, NATURE COMMUNICATIONS, , 13, - (2022 )
• Reprogramming of T cellderived small extracellular vesicles using IL2 surface engineering induces potent anticancer effects through miRNA delivery, Journal of Extracellular Vesicles, , 11, e12287- (2022 )
• Probioticsderived metabolite ameliorates skin allergy by promoting differentiation of FOXP3 regulatory T cells, Journal of Allergy and Clinical Immunology, , 147, 1517-1521 (2021 )
• Commensal Microbiome Expands T gamma delta 17 Cells in the Lung and Promotes Particulate MatterInduced Acute Neutrophilia, FRONTIERS IN IMMUNOLOGY, , 12, - (2021 )
• hnRNP K supports the maintenance of ROR gamma circadian rhythm through ERK signaling, FASEB JOURNAL, , 35, - (2021 )
• Listeria monocytogenes Establishes Commensalism in GermFree Mice Through the Reversible Downregulation of Virulence Gene Expression, FRONTIERS IN IMMUNOLOGY, , 12, - (2021 )
• Longitudinal Label‐Free Two‐Photon Microscopy of Cellular Healing Processes in Non‐Ablative Fractional Laser Wounds, Lasers in Surgery and Medicine, , 53, 1413-1426 (2021 )
• Structural specificities of cell surface βglucan polysaccharides determine commensal yeast mediated immunomodulatory activities, NATURE COMMUNICATIONS, , 12, - (2021 )
• Structural features and immunological perception of the cell surface glycans of Lactobacillus plantarum a novel rhamnoserich polysaccharide and teichoic acids, CARBOHYDRATE POLYMERS, , 233, - (2020 )
• IRT5 Probiotics Changes Immune Modulatory Protein Expression in the Extraorbital Lacrimal Glands of an Autoimmune Dry Eye Mouse Model, INVESTIGATIVE OPHTHALMOLOGY VISUAL SCIENCE, , 61, - (2020 )
• ETS1 Suppresses Tumorigenesis of Human Breast Cancer via TransActivation of Canonical Tumor Suppressor Genes, FRONTIERS IN ONCOLOGY, , 10, - (2020 )
• Dietary Glucose Consumption Promotes RALDH Activity in Small Intestinal CD103CD11b Dendritic Cells, FRONTIERS IN IMMUNOLOGY, , 11, 1897- (2020 )
• Amelioration of Autoimmune Diabetes of NOD Mice by Immunomodulating Probiotics, FRONTIERS IN IMMUNOLOGY, , 11, - (2020 )
• Special issue on the human microbiome from symbiosis to therapy, EXPERIMENTAL AND MOLECULAR MEDICINE, , 52, 1361-1363 (2020 )
• Of men in mice the development and application of a humanized gnotobiotic mouse model for microbiome therapeutics, EXPERIMENTAL AND MOLECULAR MEDICINE, , 52, 1383-1396 (2020 )
• Harnessing the bioresponsive adhesion of immunobioglue for enhanced local immune checkpoint blockade therapy, BIOMATERIALS, , 263, - (2020 )
• Intestinal microbiota control acute kidney injury severity by immune modulation, KIDNEY INTERNATIONAL, , 98, 932-946 (2020 )
• Effect of IRT5 probiotics on dry eye in the experimental dry eye mouse model, PLOS ONE, , 15, - (2020 )
• Ets1 suppresses atopic dermatitis by suppressing pathogenic T cell responses, JCI INSIGHT, , 4, - (2019 )
• Bifidobacterium bifidum presents on the cell surface a complex mixture of glucans and galactans with different immunological properties, CARBOHYDRATE POLYMERS, , 218, 269-278 (2019 )
• Bcl11b prevents catastrophic autoimmunity by controlling multiple aspects of a regulatory T cell gene expression program, SCIENCE ADVANCES, , 5, eaaw0706- (2019 )
• Bone marrow CX3CR1 mononuclear cells relay a systemic microbiota signal to control hematopoietic progenitors in mice, BLOOD, , 134, 1312-1322 (2019 )
• TCB2 a new antihuman interleukin2 antibody facilitates heterodimeric IL2 receptor signaling and improves antitumor immunity, ONCOIMMUNOLOGY, , 9, - (2019 )
• Lactobacillus pentosus Modulates Immune Response by Inducing IL10 Producing Tr1 Cells, IMMUNE NETWORK, , 19, - (2019 )
• LocusSpecific Reversible DNA Methylation Regulates Transient IL10 Expression in Th1 Cells, JOURNAL OF IMMUNOLOGY, , 200, 1865-1875 (2018 )
• Hypoxiainducible factor1 HIF1 activation in myeloid cells accelerates DSSinduced colitis progression in mice, Disease Models Mechanisms, , 11, - (2018 )
• Spontaneous Proliferation of CD4 T Cells in RAGDeficient Hosts Promotes AntigenIndependent but IL2Dependent Strong Proliferative Response of Naive CD8 T Cells, FRONTIERS IN IMMUNOLOGY, , 9, - (2018 )
• T cell microvilli constitute immunological synaptosomes that carry messages to antigenpresenting cells, NATURE COMMUNICATIONS, , 9, - (2018 )
• Twophoton microscopy of Paneth cells in the small intestine of live mice, SCIENTIFIC REPORTS, , 8, - (2018 )
• Effect of probiotics treatment on dry eyes in a mouse model of Sjogrens Syndrome, Investigative Ophthalmology and Visual Science, , 59, - (2018 )
• Cell surface polysaccharides of Bifidobacterium bifidum induce the generation of Foxp3 regulatory T cells, Science immunology, , 3, 6975- (2018 )
• Inflammationinduced Id2 promotes plasticity in regulatory T cells, NATURE COMMUNICATIONS, , 9, - (2018 )
• The transcription factor Foxp1 preserves integrity of an active Foxp3 locus in extrathymic Treg cells, NATURE COMMUNICATIONS, , 9, - (2018 )
• Probiotics as a Potential Immunomodulating Pharmabiotics in Allergic Diseases Current Status and Future Prospects, ALLERGY ASTHMA IMMUNOLOGY RESEARCH, , 10, 575-590 (2018 )
• Upregulation of Ets1 expression by NFATc2 and NFKB1RELA promotes breast cancer cell invasiveness, Oncogenesis, , 7, 91- (2018 )
• The Transcription Factor Ets1 Suppresses T Follicular Helper Type 2 Cell Differentiation to Halt the Onset of Systemic Lupus Erythematosus, IMMUNITY, , 49, 1034-+ (2018 )
• Modulation of gut microbiota and delayed immunosenescence as a result of syringaresinol consumption in middleaged mice, SCIENTIFIC REPORTS, , 7, 41667- (2017 )
• House Dust Mite Increases proTh2 Cytokines IL25 and IL33 via the Activation of TLR16 Signaling, JOURNAL OF INVESTIGATIVE DERMATOLOGY, , 137, 2354-2361 (2017 )
• NFAT1 Regulates Systemic Autoimmunity through the Modulation of a Dendritic Cell Property, JOURNAL OF IMMUNOLOGY, , 199, 3051-3062 (2017 )
• Targeted Inhibition of the NCOA1STAT6 ProteinProtein Interaction, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, , 139, 16056-16059 (2017 )
• IL4 ReceptorTargeted Proapoptotic Peptide Blocks Tumor Growth and Metastasis by Enhancing Antitumor Immunity, MOLECULAR CANCER THERAPEUTICS, , 16, 2803-2816 (2017 )
• GutSpecific Delivery of THelper 17 Cells Reduces Obesity andInsulin Resistance in Mice, Gastroenterology, , 152, 1998-2010 (2017 )
• Capicua deficiency induces autoimmunity and promotes follicular helper T cell differentiation via derepression of ETV5, Nature Communications, , 8, 10637- (2017 )
• Clinical effect of IRT5 probiotics on immune modulation of autoimmunity or alloimmunity in the eye, Nutrients, , 9, - (2017 )
• Flagellin suppresses experimental asthma by generating regulatory dendritic cells and T cells, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, , 137, 426-435 (2016 )
• Extracellular vesiclederived protein from Bifidobacterium longum alleviates food allergy through mast cell suppression, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, , 137, 507-516 (2016 )
• Transcription factor NFAT1 controls allergic contact hypersensitivity through regulation of activation induced cell death program, Scientific reports, , 6, - (2016 )
• Nuclear SpeckleRelated Protein 70 Binds to SerineArginineRich Splicing Factor1 and 2 Via an ArginineSerineLike Region and Counteracts Their Alternative Splicing Activity, JOURNAL OF BIOLOGICAL CHEMISTRY, , 291, 6169-6181 (2016 )
• Lactobacillus pentosus KF340 alleviates house dust miteinduced murine atopic dermatitis via the secretion of IL10producing splenic B10 cells, JOURNAL OF FUNCTIONAL FOODS, , 26, 258-267 (2016 )
• Cisplatin induces tolerogenic dendritic cells in response to TLR agonists via the abundant production of IL10 thereby promoting Th2and Tr1biased Tcell immunity, ONCOTARGET, , 7, 33765-33782 (2016 )
• NAMPT suppresses glucose deprivationinduced oxidative stress by increasing NADPH levels in breast cancer, ONCOGENE, , 35, 3544-3554 (2016 )
• Transcription factor NFAT1 controls allergic contact hypersensitivity through regulation of activation induced cell death program, SCIENTIFIC REPORTS, , 6, - (2016 )
• Modulation of gut microbiota and delayed immunosenescence as a result of syringaresinol consumption in middleaged mice, Scientific Reports, , 6, - (2016 )
• NFAT1 and JunB Cooperatively Regulate IL31 Gene Expression in CD4 T Cells in Health and Disease, JOURNAL OF IMMUNOLOGY, , 194, 1963-1974 (2015 )
• Lactobacillus helveticus suppresses experimental rheumatoid arthritis by reducing inflammatory T cell responses, JOURNAL OF FUNCTIONAL FOODS, , 13, 350-362 (2015 )
• Salmonella typhimurium Suppresses Tumor Growth via the ProInflammatory Cytokine Interleukin1 beta, THERANOSTICS, , 5, 1328-1342 (2015 )
• The probiotic mixture IRT5 ameliorates agedependent colitis in rats, INTERNATIONAL IMMUNOPHARMACOLOGY, , 26, 416-422 (2015 )
• Probiotics as an Immune Modulator, JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY, , 61, S103-S105 (2015 )
• TAGLN2 regulates T cell activation by stabilizing the actin cytoskeleton at the immunological synapse, JOURNAL OF CELL BIOLOGY, , 209, 143-162 (2015 )
• NAMPT suppresses glucose deprivation-induced oxidative stress by increasing NADPH levels in breast cancer, ONCOGENE, , , - (2015 )
• 6Methoxyflavone Inhibits NFAT Translocation into the Nucleus and Suppresses T Cell Activation, JOURNAL OF IMMUNOLOGY, , 193, 2772-2783 (2014 )
• Role of Blimp1 in programing Th effector cells into IL10 producers, JOURNAL OF EXPERIMENTAL MEDICINE, , 211, 1807-1819 (2014 )
• HypoxiaInducible Factor2 alpha Is an Essential Catabolic Regulator of Inflammatory Rheumatoid Arthritis, PLOS BIOLOGY, , 12, - (2014 )

Invited Talk or Presentations

• Microbiome Therapeutics for Inflammatory Disorders and Cancer, , 0, 0, - (2024)
• Microbiome therapeutics for inflammatory disorders and cancer, , 0, 0, - (2024)
• Microbiome therapeutics for inflammatory disorders and cancer, , 0, 0, - (2024)
• Bifidobacterium bifidum Probiotic Science to Live Therapeutic Product, , 0, 0, - (2024)
• Structure And Functional Correlation Of BetaGlucan In Immune Modulation, , 0, 0, - (2024)
• From Probiotics to Live Biotherapeutic Products A Journey in Science and Innovation, , 0, 0, - (2024)
• Microbiome Therapeutics for Inflammatory disorders and Cancer, , 0, 0, - (2024)
• The 7th Annual Conference of Taiwan Microbiota Consortium ACTMC The 2nd Annual Conference of Asia Pacific Microbiota Consortium APMC Keynote speaker Microbiome Therapeutics for Autoimmunity and Cancer April 27 Kaohsiung Taiwan, , 0, 0, - (2024)
• Modulation of Iron Sequestration by Commensal Microbes to Augment Tumor Immunity, , 0, 0, - (2024)
• Efficacy and Mode of Action of IMB002 for Inflammatory Disorders, , 0, 0, - (2024)
• 마이크로바이옴 타겟 치료제 현황과 전망 Current Status and Future Prospective of Microbiome Therapeutics, 마이크로바이옴 타겟 치료제 현황과 전망 Current Status and Future Prospective of Microbiome Therapeutics, 0, 0, - (2019)
• Immunotherapy and the Role of Gut Microbiome, Immunotherapy and the Role of Gut Microbiome, 0, 0, - (2019)
• Ets1 a Guardian of T Follicular Helper Cell Differentiation and SLE Development , Ets1 a Guardian of T Follicular Helper Cell Differentiation and SLE Development, 0, 0, - (2019)
• Current status and future perspective of Probiotics and Pharmabiotics, Current status and future perspective of Probiotics and Pharmabiotics, 0, 0, - (2019)
• How to Develop Probiotics as Immunomodulatory Pharmabiotics , How to Develop Probiotics as Immunomodulatory Pharmabiotics, 0, 0, - (2019)
• Modulation of host immunity by rationally selected probiotics , Modulation of host immunity by rationally selected probiotics, 0, 0, - (2019)
• Modulation of host immunity by targeting microbiome, Modulation of host immunity by targeting microbiome, 0, 0, - (2018)
• How to develop probiotics as an evidencebased functional products, How to develop probiotics as an evidencebased functional products, 0, 0, - (2018)
• How to Develop Probiotics as Immunemodulatory Pharmabiotics, How to Develop Probiotics as Immunemodulatory Pharmabiotics, 0, 0, - (2018)
• Mining of probiotic strains for immune modulation, IFFA 2018 ISBN 9786167820569, 0, 0, - (2018)
• Mining of probiotic strains for immune modulation, The First International Conference on Innovation of Functional Foods in Asia IFFA 2018, 0, 0, - (2018)
• Reprogramming of the Immune System by Rationally Selected Probiotics, 45th KSCB Winter Conference 2018, 0, 0, - (2018)
• Reprogramming of the Immune System by Rationally Selected Probiotics , Reprogramming of the Immune System by Rationally Selected Probiotics, 0, 0, - (2018)
• Reprogramming of the immune system by rationally selected probiotics, , 0, 0, - (2017)
• Ets1 suppresses T follicular helper type 2 cell differentiation and halts the onset of Lupus disease, KAI International Meeting 2017, 0, 0, - (2017)
• Ets1deficient CD4 T cells contributes to the increased Th17 and Th22 responses in atopic dermatitis, KAI International Meeting 2017, 0, 0, - (2017)
• Inflammationinduced Id2 Drives Plasticity in Regulatory T cells, KAI International Meeting 2017, 0, 0, - (2017)
• Gut matters in health and disease reprogramming of the immune system by rationally selected probiotics, 20th Bomun Symposium, 0, 0, - (2017)
• Modes of Actions of Rationally Selected Probiotics as an Immunomodulator, The 26th International KOGO Annual Conference, 0, 0, - (2017)
• Rationally Selected Probiotics as an immunomodulator effector molecules and modes of actions, , 0, 0, - (2017)
• Rationally Selected Probiotics as an Immune Modulator How Does It Work, The 9th Asian Conference on Lactic Acid Bacteria, 0, 0, - (2017)
• Rationally Selected Probiotics as an Immune Modulator How Does It Work, International Scientific Conference Probiotics and Prebiotics 2017, 0, 0, - (2017)
• Capsular Polysaccharide of Bifidobacterium bifidum Induces Functional Regulatory T Cells, , 0, 0, - (2016)
• Rationally Selected Probiotics as an Immune modulator How does it work, , 0, 0, - (2016)
• Capsular Polysaccharide of Bifidobacterium bifidum Induces Functional Regulatory T Cells, , 0, 0, - (2016)
• Transcription Factor Ets1 Negatively Regulates the Generation of Peripheral Treg Cells, , 0, 0, - (2016)
• Regulation of regulatory T cells by rationally selected probiotics attenuates allergic contact dermatitis, , 0, 0, - (2016)
• Lactobacillus pentosus 340 induces Tr1 like cells and suppresses Th17 immune responses, , 0, 0, - (2016)
• Rationally selected probiotics for hyperimmune disorders, , 0, 0, - (2016)
• Probiotics as an Immune Modulator, , 0, 0, - (2016)
• Rationally Selected Probiotics as an Immune Modulator, , 0, 0, - (2016)
• Probiotics for Hyperimmune Disorders Selection and Modeofaction, , 0, 0, - (2016)
• How do develop functional probiotics for immune modulation, , 0, 0, - (2016)
• Rationally Selected Probiotics as an Immune Modulator, , 0, 0, - (2016)
• Probiotics as an immunomodulator How does it work, , 0, 0, - (2016)
• Mechanism of Intestinal mucosal tolerance to commensal microbiota, , 0, 0, - (2016)
• Rationally Selected Probiotics for Hyperimmune Disorders, , 0, 0, - (2016)
• Probiotics as an immune modulator How does it work, , 0, 0, - (2016)
• Rationally selected probiotics as an immunomodulator for hyperimmune disorders, , 0, 0, - (2016)
• Rationally selected probiotics as an immunomodulator How dose it work, , 0, 0, - (2016)
• Rationally selected probiotics as an immune modulator for hyperimmune disorders, , 0, 0, - (2015)
• Generation of inducible regulatory T cells by commensal probiotics, , 0, 0, - (2015)
• Extracellular vesiclederived protein from Bifidobacterium longum alleviates food allergy through suppression of mast cells, , 0, 0, - (2015)
• Lactobacillus pentosus suppresses experimental atopic dermatitis by reducing Th17 responses, , 0, 0, - (2015)
• Transcription factor NFAT1 controls allergic contact hypersensitivity through regulation of activation induced cell death program, , 0, 0, - (2015)
• Transcription factor Ets1 regulates T cell activation via controlling of alternative splicing, , 0, 0, - (2015)
• Alteration of gut microbiota by probiotics administration to modulate hyperimmune disorders, , 0, 0, - (2015)
• Inhibitory role of the transcription factor Ets1 in the generation of inducible regulatory T cells, , 0, 0, - (2015)
• Probiotics as an Immunomodulator for Hyperimmune Disorders, , 0, 0, - (2015)
• 프로바이오틱스와 면역 조절, , 0, 0, - (2015)
• 발효미생물 프로바이오틱스와 면역조절기능, , 0, 0, - (2015)
• Generation of inducible regulatory T cells by commensal probiotics, , 0, 0, - (2015)
• Rationally selected probiotics as an immune modulator for hyperimmune disorders, , 0, 0, - (2015)
• Mechanisms of Action of Probiotics in Immune Modulation, , 0, 0, - (2015)
• T Cell Biology Immune Disorders Microbiome and Immune Regulation, , 0, 0, - (2015)
• Alteration of gut microbiota by probiotics administration to modulate hyperimmune disorders, , 0, 0, - (2015)
• Probiotics as an immunomodulatoy agent, , 0, 0, - (2015)
• Probiotics as an Immune Modulator for Hyperimmune Disorders, , 0, 0, - (2015)
• NFAT2 and RelA cooperatively regulates IL10 gene transcription in B cells through DNA looping, , 0, 0, - (2015)
• Probioticinduced alteration of gut microbiota regulates hyperimmune disorders, , 0, 0, - (2015)
• Tailored probiotics for hyperimmune disorders, , 0, 0, - (2014)
• Progressive epigenetic regulation of IL10 gene expression during Th1 and Th2 differentiation, , 0, 0, - (2014)
• L helveticus suppresses experimental rheumatoid arthritis by reducing inflammatory T cell responses, , 0, 0, - (2014)
• Effect of probiotics administration on gut microbiota composition, , 0, 0, - (2014)
• Tailored probiotics for hyperimmune disorders, , 0, 0, - (2014)
• Alteration of gut microbiota by probiotics administration modulates hyperimmune disorders, , 0, 0, - (2014)
• Alteration of gut microbiota to modulate allergic disorders, , 0, 0, - (2014)
• Modulation of Gut Immunity by Probiotics Ameliorates Hyperimmune Disorders, , 0, 0, - (2014)
• Modulation of Gut Immunity by Probiotics Ameliorates Hyperimmune Disorders, , 0, 0, - (2014)
• Probiotics as an Immune Modulator for Hyperimmune Disorders, , 0, 0, - (2014)
• Progressive Epigenetic Modification Determines Diffrential IL10 Expression in CD4 T cell, , 0, 0, - (2014)